Sympathetic nerve cell destruction in newborn mammals by 6-hydroxydopamine.
نویسندگان
چکیده
A selective and permanent destruction of sympathetic ganglia was achieved by injecting 6-hydroxydopamine in newborn animals. A lifelong chemical sympathectomy may thus be obtained. The process of cell damage and destruction is substantially different from that produced with an antiserum to a specific nerve growth factor.
منابع مشابه
Neonatal 6-hydroxydopamine treatment eliminates cholinergic sympathetic innervation and induces sensory sprouting in rat sweat glands.
Previous studies of the development of cholinergic sympathetic innervation of sweat glands in rat footpads suggested that these terminals initially exhibit noradrenergic properties which are lost as the glands and their innervation mature. We have treated neonatal and adult rats with 6-hydroxydopamine (6-OHDA), a toxic congener of norepinephrine, and compared its effects on the cholinergic symp...
متن کاملBiochemical and functional evaluation of the sympathectomy produced by the administration of guanethidine to newborn rats.
The administration of guanethidine to newborn rats has been shown by morphological criteria to destroy sympathetic neurons. Newborn rats were injected with guanethidine (50-100 mg/kg/day for 20 days). Upon maturation (at 10 weeks old), the degree of destruction of the sympathetic nervous system (sympathectomy) was assessed. Marked decreases (80-98%) in the norepinephrine concentration in severa...
متن کاملTreatment with 6-hydroxydopamine and colchicine decreases nerve growth factor levels in sympathetic ganglia and increases them in the corresponding target tissues.
A two-site enzyme immunoassay was used to determine the nerve growth factor (NGF) contents of sympathetic ganglia and their corresponding target tissues in adult rats. The destruction of sympathetic nerve terminals by 6-hydroxydopamine (6-OHDA) and the blockade of axonal transport by colchicine resulted in a rapid increase in the NGF levels of sympathetically innervated organs and a rapid decre...
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متن کاملImpaired Glucagon Response to Sympathetic Nerve Stimulation in the BB Diabetic Rat: an Effect of early Sympathetic Islet Neuropathy (eSIN)
We investigated the functional impact of a recently described islet-specific loss of sympathetic nerves that occurs soon after the autoimmune destruction of beta cells in the BB diabetic rat (1). We found that the portal venous glucagon response to sympathetic nerve stimulation (SNS) was markedly impaired in newly diabetic BB rats (BB D). We next found a normal glucagon response to intravenous ...
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 65 1 شماره
صفحات -
تاریخ انتشار 1970